‘Hardcore’ OX40+ immunosuppressive regulatory T cells in hepatic cirrhosis and cancer
نویسندگان
چکیده
Human regulatory T cells (Tregs) comprise an array of distinct subsets displaying diverse functions in response to microenvironmental signals. Here, we review our recent findings demonstrating the preferential accumulation of uncommitted, Th1-like and OX40- Tregs in non-cirrhotic tissues in contrast to the presence of committed, Th1-suppressing and OX40+ Tregs in cirrhotic and tumor contexts in human liver affected by chronic hepatitis C.
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2014